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Drug rash with eosinophilia and systemic symptoms secondary to sulfasalazine
Author(s) -
Rosenbaum Jeremy,
Alex George,
Roberts Hugh,
Orchard David
Publication year - 2010
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.2009.01660.x
Subject(s) - medicine , sulfasalazine , eosinophilia , rash , differential diagnosis , disease , intensive care medicine , dermatology , anxiety , pediatrics , immunology , psychiatry , pathology , ulcerative colitis
A severe cutaneous eruption in an unwell patient can be a major cause of physician anxiety. With numerous differential diagnoses, an early accurate diagnosis can be challenging. infectious causes are the most important to exclude in a timely manner and drug rash and eosinophilia with systemic symptoms (DRESS) is another differential diagnosis that should be considered in children. This hypersensitivity reaction is associated with multisystem involvement. Children with underlying chronic diseases may have impairment of normal metabolic pathways and are also often on multiple medications. Therefore, drugs should always be considered in the aetiopathology of any new symptoms and signs. This case report informs readers of the association of sulfasalazine and DRESS in an 11‐year‐old with inflammatory bowel disease and discusses its pathogenesis and treatment. Increased awareness of this disorder will hopefully lead to increased reporting and consequently illuminate the syndrome more clearly and help guide its prevention and treatment.