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Massive acute haemolysis and severe neonatal hyperbilirubinemia in glucose‐6‐phosphate dehydrogenase‐deficient preterm triplets
Author(s) -
Shah Varsha A,
Yeo Cheo Lian
Publication year - 2007
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.2007.01091.x
Subject(s) - haemolysis , medicine , jaundice , glucose 6 phosphate dehydrogenase , glucosephosphate dehydrogenase deficiency , glucose 6 phosphate dehydrogenase deficiency , pediatrics , cord blood , exchange transfusion , immunology , dehydrogenase , enzyme , biochemistry , biology
Premature triplets (2 boys and 1 girl) were delivered at 34 weeks, with both boys identified as Glucose‐6‐phosphate dehydrogenase (G6PD) deficient. Despite having similar quantitative levels of G6PD in their cord blood, only one boy had severe hyperbilirubinemia and anaemia caused by acute haemolysis requiring exchange transfusion. G6PD‐deficient infants with the similar genetic, demographic, maternal, clinical factors and G6PD quantification levels can have different severity of presentation of neonatal jaundice in similar environmental set up. This supports the massive acute haemolysis can occur in infant with G6PD deficiency in the absence of any obvious blood group incompatibilities, infection, or ingestion of oxidising agents known to trigger haemolysis.