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How to use medicines in children: Principles of paediatric clinical pharmacology
Author(s) -
Sinha Yashwant,
Cranswick Noel E
Publication year - 2007
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.2007.00970.x
Subject(s) - medicine , clinical pharmacology , dosing , intensive care medicine , clinical trial , medline , pediatrics , pharmacology , political science , law
Knowledge of drug administration in children and infants has significantly lagged behind that of adults. Despite several paediatric therapeutic mishaps that have been a catalyst for major regulatory reform, the majority of registered medicines do not have indications or dosing for children. This paper will briefly summarise key issues in paediatric pharmacology, including differences in prescribing for children, off‐label and unlicensed prescribing and conduct of paediatric clinical trials. A particular emphasis will placed on the situation in Australia.