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Tumour surveillance in Beckwith–Wiedemann syndrome and hemihyperplasia: A critical review of the evidence and suggested guidelines for local practice
Author(s) -
Tan Tiong Y,
Amor David J
Publication year - 2006
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.2006.00908.x
Subject(s) - medicine , beckwith–wiedemann syndrome , intensive care medicine , clinical practice , family medicine , genetics , gene expression , gene , dna methylation , biology
There is strong evidence for an association between overgrowth disorders such as Beckwith–Wiedemann syndrome and the development of neoplasia. An increased cancer risk has also been observed in individuals with isolated hemihyperplasia. We critically review the evidence for tumour surveillance in Beckwith–Wiedemann syndrome and isolated hemihyperplasia and suggest local practice guidelines.