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Fetal surgery for congenital diaphragmatic hernia
Author(s) -
Grethel Erich J,
Nobuhara Kerilyn K
Publication year - 2006
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.2006.00802.x
Subject(s) - medicine , congenital diaphragmatic hernia , fetus , diaphragmatic breathing , diaphragmatic hernia , credence , psychological intervention , hernia , intensive care medicine , pediatrics , surgery , pregnancy , pathology , statistics , genetics , alternative medicine , mathematics , psychiatry , biology
Congenital diaphragmatic hernia (CDH) continues to account for significant mortality in neonates. Advances in postnatal therapies have reduced mortality rates in the less severely affected infants, though surviving infants continue to display significant comorbid conditions. The history of fetal treatment for CDH is a microcosm for the development of fetal therapy in general. This paper traces this history from early clinical observations and imaging advances to experimental animal studies and finally to safe human application and development of clinical trails. Encouraging recent results and improved outcomes lend credence to the idea than prenatal interventions may give clinicians and families more hope.