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Alloimmune neonatal neutropenia: Can we afford the consequences of a missed diagnosis?
Author(s) -
Williams Bronwyn A,
Fung YL
Publication year - 2006
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.2006.00774.x
Subject(s) - medicine , neutropenia , intensive care medicine , pediatrics , surgery , chemotherapy
The incidence of alloimmune neonatal neutropenia (ANN) is poorly defined. The reported incidence is less than or equal to 0.1%. This prospective study of unselected pregnancies found an incidence of 0.81% based on results of screening 247 ‘full term’ cord blood samples. Alloimmune neonatal neutropenia occurred more frequently in this population than expected from published historical data. Advances in techniques for antineutrophil antibody screening may have contributed to the higher incidence found in this study. The frequency of ANN supports increased surveillance and confirmatory serological testing in infants with unexplained neutropenia.