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Reye's syndrome developing in an infant on treatment of Kawasaki syndrome
Author(s) -
Wei ChihMing,
Chen HueyLing,
Lee PingIng,
Chen ChongMing,
Ma ChunYi,
Hwu WuhLiang
Publication year - 2005
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.2005.00617.x
Subject(s) - medicine , tachypnea , lethargy , aspirin , coagulopathy , reye syndrome , kawasaki disease , reye's syndrome , encephalopathy , hyperammonemia , pediatrics , surgery , tachycardia , gastroenterology , artery
Aspirin is commonly used as an anti‐inflammatory therapy for Kawasaki syndrome. Early initiation with high dose aspirin (80 to >100 mg/kg per day), followed by low‐dose therapy at the afebrile stage, has been often used to reduce morbidity and mortality in coronary complications. We report a 10‐month‐old infant who was diagnosed with Kawasaki syndrome. Sudden onset of poor activity, poor appetite, lethargy, tachycardia, tachypnea, hepatomegaly, increased AST/ALT, coagulopathy and hyperammonemia developed 3 days after the high‐dose aspirin therapy. His histopathological and ultrastructural findings from the liver biopsy were compatible with Reye's syndrome. He recovered completely, and there was no recurrence.