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Cyclic bisphosphonate therapy in osteogenesis imperfecta type V
Author(s) -
Fleming F,
Woodhead HJ,
Briody JN,
Hall J,
Cowell CT,
Ault J,
Kozlowski K,
Sillence DO
Publication year - 2005
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.2005.00567.x
Subject(s) - medicine , osteogenesis imperfecta , osteoporosis , bisphosphonate , regimen , radiography , surgery , pediatrics , dentistry , pathology
The clinical and radiographic features and management of a young person with recently delineated Osteogenesis Imperfecta Type V is described. A female aged 9 years presented with a history of multiple fractures since 3 years of age and bilateral dislocation of the elbows from infancy. She was commenced on a low dose frequent regimen of cyclic intravenous pamidronate, which resulted in progressive improvement in bone density, reduced fracture frequency and remission of symptoms of osteoporosis.