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Maternal haemolysis, elevated liver enzymes and low platelets syndrome: Perinatal and neurodevelopmental neonatal outcomes for infants weighing less than 1250 g
Author(s) -
Singhal N,
Amin HJ,
Pollard JK,
Tough SC,
Johnston DW,
Clark DJ,
Sauve R
Publication year - 2004
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.2004.00311.x
Subject(s) - medicine , haemolysis , elevated liver enzymes , liver enzyme , platelet , pregnancy , pediatrics , immunology , genetics , biology
Objectives: To study mortality and short‐term morbidity of infants born to women with HELLP (haemolysis, elevated liver enzymes, and low platelets) syndrome and to compare the long‐term neurodevelopmental morbidity of a subgroup with birth weight (BWT) less than 1250 g (study group) with weight matched controls. Methods: Retrospective chart review and prospective neurodevelopmental follow‐up through a Perinatal Follow‐up clinic. Analysis of perinatal and neonatal data for women diagnosed with HELLP from 1993 to 1996. Neurodevelopmental outcome for the study group was compared to a group of weight matched controls. Results: A total of 109 infants (mean gestational age 32.6 weeks, mean BWT 1766 g) were born to 104 women with HELLP syndrome. There was a significant decrease in mortality ( P = 0.002) and morbidity ( P < 0.05) with increasing gestational age and birthweight. No significant differences in neonatal mortality and morbidity were present between the infants weighing less than 1250 g study and weight matched control group. However, at 3 years, the study group had fewer children with cerebral palsy ( P = 0.024) and mental disability ( P trend = 0.07). Mean cognitive index was 99 versus 91 in the controls ( P = 0.101). Conclusion: Improved health outcomes occur with increased gestational age. Infants with BWT less than 1250 g born to women with HELLP syndrome were not at risk of increased neurodevelopmental disability compared to controls.