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Fatal necrotizing pneumonia caused by group A streptococcus
Author(s) -
Cengiz AB,
Kanra G,
Cag^lar M,
Kara A,
Güçer S¸,
İnce T
Publication year - 2004
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.2004.00296.x
Subject(s) - medicine , streptococcus pyogenes , pneumonia , streptococcus pneumoniae , autopsy , sepsis , streptococcus , bacterial pneumonia , lung , pathology , necrosis , immunology , microbiology and biotechnology , staphylococcus aureus , antibiotics , bacteria , biology , genetics
Group A streptococcus (GAS) causes invasive, non‐invasive and non‐suppurative diseases. Pneumonia is one of the invasive infections caused by GAS. Although GAS is a significant and serious cause of childhood pneumonia, it is often overlooked clinically. Similarly, the recent literature is surprisingly scant on reports of GAS pneumonia and concentrates mainly on varicella‐associated invasive GAS diseases. In this case report, we present a previously healthy 7‐year‐old child with community‐acquired pneumonia that progressed rapidly and resulted in sepsis, respiratory failure and death. In both blood and pleural fluid cultures, Streptococcus pyogenes were isolated. On autopsy, macroscopic examination revealed that the lung tissue appeared to have lost its normal architecture. Necrosis was present and the lung had a spongy appearance with some solid areas. The light microscopy revealed massive oedema, haemorrhages, intense inflammatory cell infiltration and necrosis. This case report highlights the need for consideration of invasive GAS infection in the event of severe, rapidly progressing pneumonia in children.