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Minimal haemolysis in blood co‐infused with amino acid and dextrose solutions in vitro
Author(s) -
JANKOV RP,
ROY RND
Publication year - 1997
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1997.tb01590.x
Subject(s) - haemolysis , medicine , saline , in vitro , amino acid , anesthesia , biochemistry , chemistry , immunology
Objective: To examine the haemolytic effects of amino acid and dextrose solutions on co‐infused packed red blood cells. Methodology: An in vitro study of packed cells co‐infused at various rates with dextrose 5%, 10%, 15% and intravenous amino acid solution (Vamin; Kabi‐Pharmacia, Baxter Healthcare Pty Ltd) in dextrose 5%, 10% and 15%. The degree of haemolysis was measured as free oxyhaemoglobin by spectrophotometer. Co‐infused 0.9% saline and water were used as 0% and 100% haemolysis controls. Results: Only minimal haemolysis was observed with the solutions tested. The greatest observed amount of haemolysis was 0.14%. Conclusions: Co‐infusion of packed red blood cells with dextrose and amino acid solutions at the concentrations and infusion rates commonly used, in neonatal care, does not cause clinically important haemolysis.