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Strategies to prevent chronic neonatal lung disease
Author(s) -
SCHINDLER MB
Publication year - 1996
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1996.tb00957.x
Subject(s) - medicine , oxygen toxicity , lung , nitric oxide , anesthesia , mechanical ventilation , lung disease , respiratory disease , ventilation (architecture) , inflammation , toxicity , pathogenesis , respiratory system , mechanical engineering , engineering
The pathogenesis of chronic neonatal lung disease involves the combined iatrogenic insults of oxygen toxicity and barotrauma in addition to lung inflammation. Newer ventilator strategies using smaller tidal volumes (3–7 mL/kg) in order to avoid overdistension, higher positive end‐respiratory pressure and lower peak inspiratory pressures decrease barotrauma. Earlier reduction of F i O 2 through the use of surfactant, high frequency ventilation and nitric oxide reduce oxygen toxicity. Other measures include careful fluid balance, avoidance of prolonged paralysis and early steroids to decrease inflammation.