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Childhood acute lymphoblastic leukaemia presenting as jaundice
Author(s) -
ALVARO F,
JAIN M,
MORRIS LL,
RICE MS
Publication year - 1996
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1996.tb00951.x
Subject(s) - medicine , jaundice , pancytopenia , cholestasis , intrahepatic bile ducts , common bile duct , bile duct , gastroenterology , pathology , bone marrow
An unusual presentation of acute lymphoblastic leukaemia (ALL) in a 6‐year‐old girl is reported. She presented with unilateral cervical lymphadenopathy, a mixed obstructive/cholestatic jaundice and a progressive pancytopenia. Ultrasound examination revealed an obstructed common bile duct with gross thickening of the wall of the duct and intrahepatic bile duct dilatation. The jaundice resolved with high dose intravenous (i.v.) methylprednisolone. It is postulated that this was due to infiltration of the common bile duct, given the failure to demonstrate any other cause for the bile duct pathology.