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Haemodynamic effects of differing blood transfusion rates in infants less than 1500 g
Author(s) -
NOSÈ Y,
TAMAI H,
SHIMADA S,
FUNATO M
Publication year - 1996
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1996.tb00918.x
Subject(s) - medicine , hemodynamics , anesthesia , blood transfusion , blood pressure , ductus arteriosus , intraventricular hemorrhage , cardiology , gestational age , pregnancy , biology , genetics
Objective : To investigate whether the haemodynamic effects of the standard 2‐3 h blood transfusion increases the risk for intraventricular haemorrhage (IVH) and patent ductus arteriosus (PDA) in very low birthweight infants. Methodology : In a randomized controlled study, haemodynamic changes using slow and rapid transfusion were compared. Twenty‐seven very low birthweight infants were divided between 12 h ( n = 14) and 3 h ( n = 13) transfusion groups. Blood pressure, ejection fraction (EF), anterior cerebral artery pulsatility index (Pl), blood gases, serum electrolytes and haematocrit were measured pre‐ and post‐transfusion. Infectious status was also monitored. Results : Blood pressure (48.1/25.5 vs 55.7/30.2 mmHg) and EF (0.68 vs 0.73) increased significantly during rapid transfusion ( P >0.01) but remained stable with slow transfusion. Serum potassium, base excess and incidence of infection did not increase in either group. Conclusions : Slow transfusion causes less haemodynamic disturbance than rapid transfusion, thereby preventing the potential risk for IVH and PDA.