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Acute myeloid leukaemia in patients with trisomy 21 (Down syndrome) treated by bone marrow transplantation
Author(s) -
GOLETADY A.,
POZZA L. DALLA,
SHAW P. J.,
STEVENS M. M.
Publication year - 1994
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1994.tb00634.x
Subject(s) - medicine , trisomy , myeloid leukaemia , down syndrome , bone marrow transplantation , bone marrow , myeloid , myeloid leukemia , incidence (geometry) , transplantation , cytarabine , pediatrics , genetics , physics , psychiatry , optics , biology
Patients with trisomy 21 have an increased incidence of haematological disorders, including neonatal ‘leukaemoid reaction’(transient myeloproliferative disorder [TMD]) and acute leukaemias. In the past it has been felt that patients with trisomy 21 and acute leukaemia do not tolerate, and hence may not warrant, therapy as intensive as those without the syndrome. The present authors' experience and the current literature do not support this view. Two cases are reported of acute myeloid leukaemia in children with trisomy 21, successfully treated with intensive chemotherapy and bone marrow transplantation.