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Combined therapy with growth hormone and oxandrolone in adolescent girls with Turner syndrome
Author(s) -
LU P. W.,
COWELL C. T.
Publication year - 1993
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1993.tb00438.x
Subject(s) - oxandrolone , medicine , turner syndrome , bone age , human growth hormone , growth hormone , turner's syndrome , bone maturation , endocrinology , pediatrics , hormone
Five adolescent girls with Turner syndrome (mean age 13.9 years, mean bone age 12.0 years) were treated with both recombinant human growth hormone (rhGH) and oxandrolone for 2 years with an average increment in height of 13.4 cm. The mean bone age advanced by only 1.2 years, providing an increase in the mean estimated mature height of 9.2 cm. We conclude that rhGH and oxandrolone benefit older teenagers with Turner syndrome because of an increased growth rate with slow progression of skeletal maturation.