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Fetal lung growth in laryngeal atresia and tracheal agenesis
Author(s) -
SCURRY J. P.,
ADAMSON T. M.,
CUSSEN L. J.
Publication year - 1989
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1989.tb01413.x
Subject(s) - medicine , oligohydramnios , atresia , pulmonary hypoplasia , lung , hypoplasia , fetus , larynx , agenesis , airway obstruction , respiratory distress , renal agenesis , anatomy , airway , surgery , kidney , pregnancy , genetics , biology
Three cases of airway obstruction in fetuses born at 21, 32 and 40 weeks gestation are reported. The first had laryngeal atresia, cystic dysplastic kidneys, oligohydramnios and immense fluid‐filled lungs. The second had upper tracheal agenesis, a tracheo‐oesophageal fistula, a cystic dysplastic horseshoe kidney, oligohydramnios and normal‐sized lungs. The third had a pin‐hole mucosal tract through an otherwise atretic larynx, normal kidneys, no oligohydramnios and normal‐sized lungs. Lung weight:body weight ratios, radial alveolar or radial canalicular counts and point‐counting of sections of lungs in cases 1 and 2 show that laryngeal or tracheal obstruction may prevent or reduce the pulmonary hypoplasia associated with renal dysplasia, and in cases 2 and 3, that grossly enlarged, hyperplastic lungs may not be seen unless obstruction is complete.