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Micro‐angiopathic haemolysis, thrombocytopenia and nephrotic syndrome associated with membranous nephropathy in a Vietnamese boy
Author(s) -
McDONALD D. T.,
ROY L. P.
Publication year - 1988
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1988.tb01372.x
Subject(s) - medicine , membranous nephropathy , nephrotic syndrome , haemolysis , vietnamese , glomerulonephritis , nephropathy , immunology , kidney , endocrinology , diabetes mellitus , linguistics , philosophy
The unique association of idiopathic diffuse membranous nephropathy and micro‐angiopathic haemolyi anaemia and thrombocytopenia is described. A 7 year old Vietnamese boy with a 1‐month history of anaemia resistant to oral iron supplements presented with acute onset of nephrotic syndrome. Investigations revealed a micro‐angiopath haemolytic anaemia and thrombocytopenia. There was no associated oliguria or uraemia. Diffuse membranous nephropathy was diagnosed by renal biopsy. Apart from a fourfold rise in enterovirus titres, no underlying cause for the haematological or glomerular abnormalities was found. There was an apparent, partial haematological response to fresh frozen plasma infusions, but not to Vitamin E.