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The selenium status of children with phenylketonuria: Results of selenium supplementation
Author(s) -
LIPSON A.,
MASTERS H.,
O'HALLORAN M.,
THOMPSON S.,
COVENEY J.,
YU J.
Publication year - 1988
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1988.tb00304.x
Subject(s) - selenium , medicine , glutathione peroxidase , vitamin e , selenium deficiency , endocrinology , vitamin c , physiology , peroxidase , micronutrient , antioxidant , biochemistry , oxidative stress , enzyme , superoxide dismutase , biology , pathology , chemistry , organic chemistry
The selenium status of children with phenylketonuria on a synthetic low phenylalanine diet was assessed. Correlation between blood selenium and red cell glutathione peroxidase was unsatisfactory ( r = 0.65) due to the poor discrimination of red cell glutathione peroxidase with a low selenium diet. No symptoms of deficiency were observed. Supplementation with 50 μg per week of selenium as brewers yeast tablets over a period of 6 months significantly increased the blood selenium of the phenylketonuric children. Plasma Vitamin E levels were within normal limits. The supplementation effectively doubled their selenium intake to 15–17 μg per day, which is probably sufficient for this group with an adequate Vitamin E status, though considerably lower than the recommended minimum intake of 50 μg per day.