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An immunogenetic study of juvenile chronic arthritis
Author(s) -
MANNERS P. J.,
DAWKINS R. L.,
McCLUSKEY J.,
HEWSON P. H.
Publication year - 1986
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1986.tb02157.x
Subject(s) - medicine , juvenile , juvenile chronic arthritis , arthritis , immunology , genetics , biology
Ninety‐seven patients from Western Australia and Victoria suffering from juvenile chronic arthritis (JCA) for longer than 1 year were studied with particular reference to immunogenetic markers in the sub‐groups of the disease. In the pauci‐articular group, the antigens DR5, DR8 and BW35 were increased in frequency. The phenotypes within the sub‐groups appeared distinctive despite the absence of any increase in the frequency of single antigens. Complement allotyping did not prove to be different from controls or within the sub‐groups for JCA. This study supports the concept that patients with JCA have specific genetic characteristics and that sub‐groups of the disease are genetically distinct.