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Serum pancreatic enzyme levels in cystic fibrosis heterozygotes after secretin and cholecystokinin infusion
Author(s) -
MITCHELL E. A.,
ELLIOTT R. B.
Publication year - 1982
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1982.tb02003.x
Subject(s) - medicine , cystic fibrosis , pancreatic enzymes , secretin , cholecystokinin , heterozygote advantage , endocrinology , pancreatic disease , pancreas , biochemistry , gene , receptor , allele , chemistry
. The response of serum trypsinogen and amylase to pancreatic stimulation was examined in heterozygotes for cystic fibrosis (CF) and normal subjects. Serum trypsinogen rose significantly from the baseline in CF heterozygotes at 30 (p<0.001), 60 (p<0.01) and 120 minutes (p<0.05), but at only 30 minutes (p<0.02) in normal subjects. The mean serum trypsinogen level at 30 and 60 minutes was significantly higher in CF heterozygotes than normal subjects (both p<0.05). There was no change in total serum α‐amylase levels. These results suggest that CF heterozygotes show either partially obstructed pancreatic ducts or pancreatic acini which secrete trypsinogen at an increased rate when stimulated.