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Failure of oral N‐acetylcysteine to improve the malabsorption of cystic fibrosis
Author(s) -
MITCHELL E. A.,
ELLIOTT R. B.
Publication year - 1981
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1981.tb01940.x
Subject(s) - malabsorption , medicine , cystic fibrosis , acetylcysteine , gastroenterology , exocrine pancreatic insufficiency , placebo , pathology , biochemistry , chemistry , alternative medicine , antioxidant
. Pancreatic exocrine insufficiency is an important factor in the malabsorption of cystic fibrosis, but other factors may also contribute to the steatorrhoea. It has been suggested that thickened mucinous covering of the villi forms a mechanical barrier to absorption. A double blind cross‐over placebo controlled trial of the oral mucolytic agent N‐acetylcysteine failed to improve the fat malabsorption.