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The treatment of malabsorption in cystic fibrosis with pancreatic extracts and inhibition of gastric acidity by antacids and cimetidine
Author(s) -
MITCHELL E. A.,
WESLEY ALISON W.,
ELLIOTT R. B.
Publication year - 1981
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1981.tb01911.x
Subject(s) - medicine , cimetidine , gastroenterology , cystic fibrosis , antacid , malabsorption , trypsin , pancreatic disease , pancreas , excretion , biochemistry , enzyme , chemistry
. Pancreatic extracts even in high doses usually fail to completely control steatorrhoea in cystic fibrosis (CF). Trypsin and lipase are rapidly and irreversibly inactivated by acid. Twenty‐two patients with CF entered a cross‐over trial where they received their usual dose of pancreatic extracts for four weeks, cimetidine plus pancreatic extracts for four weeks, and antacid plus pancreatic extracts for four weeks. There was a significant reduction (p < 0.05) in mean faecal fat excretion of 15.36 ± 8.54 g/day, and an improvement of the coefficient of absorption 78.2 ± 12.1% (p < 0.02) during the treatment period with pancreatic extracts alone to 12.48 ± 7.26 g/day and 83.2 ± 8.0% respectively with pancreatic extracts plus cimetidine. There was a significant improvement of the coefficient of absorption during the pancreatic extracts alone treatment period from 78.2 ± 12.1% to 82.6 ± 7.2% during the treatment period with pancreatic extracts plus antacid (p < 0.05). None of the treatments differed in their effects on weight gain, stool frequency and subjective variables (stool odour and consistency, abdominal pain and flatus).