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Metabolic Acidosis and Renal Solute Load in Relation to the Protein Intake of Low Birth Weight Malaysian Neonates
Author(s) -
JOHNSON R. O.,
JOHNSON B. H.,
RAMAN A.,
LEE E. L.,
LAM K. L.
Publication year - 1979
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1979.tb01199.x
Subject(s) - medicine , metabolic acidosis , acidosis , urea , urine osmolality , endocrinology , low birth weight , birth weight , urine , asymptomatic , physiology , biochemistry , pregnancy , chemistry , biology , genetics
Johnson, R. O., Johnson, B. H., Raman, A., Lee, E. L., and Lam, K. L. (1979) Aust. Paediatr. J. , 15, 101–106. Metabolic acidosis and renal solute load in relation to the protein intake of low birth weight Malaysian neonates. Thirty‐one low birth weight Malaysian neonates were divided into two groups for the purpose of comparing two different dilutions of modified cow's milk. One dilution supplied 2.4 g protein/100 kcal (16.9 g/l) and the other 3.3 g/100 kcal (22.5 g/l). The two milks were iso‐caloric at 69 kcal/100 ml. Clinical observation and weekly estimations of acid‐base status, plasma sodium, chloride, potassium, urea and osmolality and of urine osmolality were made during the first three weeks of life. Metabolic acidosis was observed in both groups of infants, being significantly more severe in the higher protein group. Most acidotic babies remained asymptomatic. Plasma urea and plasma and urine osmolalities were all significantly higher in the higher protein group. No case of hyperosmolality occurred. Caution is recommended when feeding cow's milk of protein density greater than 2.4 g/100 kcal to low birth weight infants.