Premium
A Fatal Case of Progressive Vaccinia — Clinical and Pathological Studies
Author(s) -
ROBINSON M. J.,
MURUGASU R.,
THONG Y. H.,
CHEN S. T.
Publication year - 1977
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1977.tb01138.x
Subject(s) - medicine , vaccinia , autopsy , pathological , spleen , lymphatic system , lymph , gastrointestinal tract , atrophy , pathology , dysplasia , immunology , biochemistry , chemistry , gene , recombinant dna
The clinical and pathological details of an infant aged 1 year with progressive vaccinia are presented. Evidence of combined cellular and humoral deficiency was obtained in this infant during life. Despite therapy with hyperimmune gammaglobulin, N‐methylisatin, B‐thiosemicarbisone (methisazone), antibiotics and transfer factor, death occurred. Autopsy revealed thymic dysplasia and atrophy of lymphoid tissue within lymph nodes, spleen, tonsils and gastrointestinal tract. Recommendations regarding the management of progressive vaccinia are made.