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Autoantibodies, Immunoglobulins and Hepatitis B Antigen in Children with Chronic Liver Disease
Author(s) -
DUBOIS R. S.
Publication year - 1976
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1976.tb02498.x
Subject(s) - medicine , biliary atresia , autoantibody , cirrhosis , antibody , hepatitis , primary biliary cirrhosis , liver disease , antigen , hepatobiliary disease , immunology , gastroenterology , liver transplantation , transplantation
Dubois, R. S. (1976).Aust. paediat. J. , 12, 163–166. Autoantibodies, immunoglohulins and hepatitis B antigen in children with chronic liver disease. Smooth muscle antibody, mitochondrial antibody, serum immunoglobulin levels and hepatitis‐B antigen (HBAg) were measured in the sera of 20 children with extra‐hepatic biliary atresia, 8 with intra‐hepatic biliary atresia and 6 with post‐hepatitic (neonatal) cirrhosis. Smooth muscle antibody was not found in any patient with post‐hepatitic cirrhosis, but was present in 4 of 20 patients with extra‐hepatic and in 4 of 8 with intra‐hepatic biliary atresia. Serum immunoglobulins, particularly IgA. were elevated in the presence of cirrhosis. Serum IgA was markedly elevated in those infants with hepatic decompensation. No patient had mitochondrial antibody, despite the presence of prolonged extra‐ or intra‐hepatic biliary obstruction. HBAg was negative in all patients.