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MEASUREMENT OF GLOMERULAR FILTRATION RATE IN NEONATES USING THE SINGLE INJECTION CLEARANCE OF 113m In‐DTPA
Author(s) -
CLARKSON J. C.,
SMIDT K. P.
Publication year - 1973
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1973.tb01879.x
Subject(s) - medicine , renal function , respiratory distress , gestational age , clearance rate , clearance , plasma clearance , urology , pregnancy , anesthesia , pharmacokinetics , biology , genetics
SYNOPSIS The glomerular filtration rate was estimated in 15 neonates by measuring the plasma clearance of 113m In‐DTPA following a single intravenous dose. 113m In‐DTPA clearance was lowest in one infant with peripheral circulatory failure and in 4 with the respiratory distress syndrome and a gestational age less than 35 weeks. Results in the other infants with miscellaneous disorders were within the expected range for normal neonates. The procedure provided a direct and rapid estimate of renal function. Further studies will be required to assess the relative importance of gestational age and the respiratory distress syndrome as determinants of renal function.