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TYROSINOSIS: REPORT OF A CASE DEMONSTRATING IN VIVO DELAY IN TYROSINE BREAKDOWN AND EXCESS RENAL LOSS OF INSULIN
Author(s) -
TOMPKINS J. R.,
HOBDAY J. D.
Publication year - 1971
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1971.tb01041.x
Subject(s) - medicine , tyrosine , catabolism , in vivo , phenylalanine , insulin , endocrinology , urine , biochemistry , metabolism , amino acid , microbiology and biotechnology , biology , chemistry
SYNOPSIS The presentation, clinical and laboratory findings of a child with tyrosinosis are described. A low tyrosine and low phenylalanine diet produced considerable improvement, Investigation demonstrated an excessive loss of insulin in the urine. An experimental in vivo measurement of the rate of catabolism of tyrosine labelled with 14 C confirmed the reported findings of a reduction in the rate of catabolism of tyrosine in vitro.