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THE CHEMICAL DIAGNOSIS OF GANGLIONEUROMA AND NEUROBLASTOMA USING RANDOM SPECIMENS OF URINE
Author(s) -
HINTERBERGER H.,
BARTHOLOMEW R. J.
Publication year - 1970
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1970.tb02846.x
Subject(s) - ganglioneuroma , homovanillic acid , medicine , neuroblastoma , urine , vanillylmandelic acid , excretion , pathology , gastroenterology , biology , genetics , receptor , serotonin , cell culture
SYNOPSIS Adrenalin, noradrenalin and dopamine, and their principal acidic metabolites 4‐hydroxy‐3‐methoxymandelic acid (vanilmandelic acid) and homovanillic acid, have been estimated in both random and 24 hour specimens of urine from 14 patients aged 7 months to 7 years with confirmed neuroblastoma or ganglioneuroma, and the results have been compared with those of 146 control subjects aged 3 months to 13 years. The study has shown that analysis of random specimens may be helpful in screening outpatients, provided that abnormal findings are subsequently confirmed by analysis of 24 hour specimens. Random specimens may also be used to monitor levels of excretion during the course of the disease. Variation in the pattern of excretion during treatment make it essential to test for several metabolites.