Premium
INTRAVENOUS GAMMA GLOBULIN THERAPY OF IMMUNOGLOBULIN DEFICIENCY DISEASES *
Author(s) -
SIMONS M. J.,
SCHUMACHER M. J.,
FOWLER R.
Publication year - 1968
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1968.tb01741.x
Subject(s) - medicine , gamma globulin , antibody , globulin , pepsin , intravenous use , immunoglobulin g , intravenous therapy , intravenous immunoglobulin therapy , immunology , gastroenterology , anesthesia , enzyme , biochemistry , chemistry
SYNOPSIS The effect of the intravenous administration of gamma globulin modified by treatment with pepsin and low pH, (I.V.G.G.), has been described. This material has been administered, as routine therapy, to 6 children with immunoglobulin abnormalities. Adequate serum IgG levels were obtained and maintained because the I.V.G.G. could be given in higher dosage than that uusally employed with the intramuscular preparation. Occurrence of untoward reactions to I.V.G.G. were observed and found to be rate dependent. Careful medical supervision is therefore essential during the entire course of the therapy.