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A BIOCHEMICAL, CLINICAL AND NUTRITIONAL ASSESSMENT OF CHILDHOOD OBESITY
Author(s) -
KNEEBONE G. M.
Publication year - 1965
Publication title -
journal of paediatrics and child health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.631
H-Index - 76
eISSN - 1440-1754
pISSN - 1034-4810
DOI - 10.1111/j.1440-1754.1965.tb02595.x
Subject(s) - medicine , nefa , obesity , endocrinology , reversion , insulin , biochemistry , chemistry , gene , phenotype
SYNOPSIS A series of 25 obese children and 10 non‐obese controls was studied during the fasting state and after oral glucose administration. Fifteen of the obese group showed a reduced response of their NEFA levels to this stimulus. This ‘metabolic’ group of children after a course of tri‐iodothyronine (T3) showed a reversion to a normal response in the NEFA levels. The ‘metabolic’ group showed a significantly greater weight loss after T3 than the ‘normal’ obese group. This finding, in children and adults, is additional evidence for an inherited basis for obesity in these subjects.