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Epidemiology, risk factors, and the promotion of pancreatic cancer: Role of the stellate cell
Author(s) -
Pandol Stephen,
Gukovskaya Anna,
Edderkoui Mouad,
Dawson David,
Eibl Guido,
Lugea Aurelia
Publication year - 2012
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2011.07013.x
Subject(s) - medicine , pancreatic cancer , epidemiology , hepatic stellate cell , promotion (chess) , cancer , politics , political science , law
There are approximately 277 000 new cases of pancreatic cancer and 266 000 deaths from pancreatic cancer annually, indicating a mortality rate of 96% of the cases diagnosed. Because of the ineffectiveness of therapies, a major emphasis needs to be placed on prevention. This paper reviews the epidemiology and risk factors for pancreatic cancer, and uses this information to propose plausible research directions for determining the biological mechanisms mediating the effects of risk factors on the promotion of pancreatic cancer, with a focus on the pancreatic stellate cell.