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Null genotype of glutathione S‐transferase Tl contributes to colorectal cancer risk in the Asian population: A meta‐analysis
Author(s) -
Zhong Shan,
Yang JiaHe,
Liu Kai,
Jiao BingHua,
Chang Zhijie
Publication year - 2012
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2011.06920.x
Subject(s) - odds ratio , meta analysis , medicine , colorectal cancer , genotype , confidence interval , subgroup analysis , population , glutathione s transferase , oncology , gastroenterology , cancer , glutathione , genetics , biology , gene , environmental health , biochemistry , enzyme
Background and Aim: Previous studies investigating the association between the glutathione S‐transferase Tl ( GSTT1 ) null genotype and colorectal cancer (CRC) risk in the Asian population have reported controversial results. Thus, a meta‐analysis was performed to clarify the effect of the GSTT1 null genotype on CRC risk in the Asian population. Methods: A comprehensive study was conducted, and 12 case‐control studies were finally included, involving a total of 4517 CRC cases and 6607 controls. Subgroup analyses were performed by the sample size. Results: A meta‐analysis of all 12 studies showed that the GSTT1 null genotype was significantly associated with an increased CRC risk in the Asian population (odds ratio [OR] = 1.10, 95% confidence interval [CI] = 1.02–1.19, the P ‐value of the OR [ P OR ] = 0.02, the value of the heterogeneity analysis [I 2 ] = 42%). A more obvious association was observed after the heterogeneity was eliminated by excluding one study (OR = 1.15, 95% CI: 1.06–1.25, P OR = 0.001, I 2 = 0%). This association was further identified by both subgroup analyses and a sensitivity analysis. Conclusions: This meta‐analysis suggests that the GSTT1 null genotype contributes to an increased colorectal cancer risk in the Asian population.