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High‐resolution impedance manometry findings in patients with nutcracker esophagus
Author(s) -
Hoshino Masato,
Sundaram Abhishek,
Juhasz Arpad,
Yano Fumiaki,
Tsuboi Kazuto,
Lee Tommy H,
Mittal Sumeet K
Publication year - 2012
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2011.06911.x
Subject(s) - medicine , high resolution manometry , dysphagia , chest pain , achalasia , spastic , esophagus , esophageal spasm , radiology , nuclear medicine , physical therapy , cerebral palsy
Background and Aim: The objective of this study was to evaluate the association between high‐resolution manometry (HRM) and impedance findings and symptoms in patients with nutcracker esophagus (NE). Methods: After institutional review board approval retrospective review of a prospectively maintained database identified patients who were diagnosed with NE as per the Chicago classification (distal contractile integral [DCI] > 5000 mmHg‐s‐cm) at Creighton University between October 2008 and October 2010. Patients with achalasia or a history of previous foregut surgery were excluded. NE patients were sub‐divided into: (i) Segmental (mean distal esophageal amplitude [DEA] at 3 and 8 cm above lower esophageal sphincter [LES] < 180 mmHg) (ii) Diffuse (mean DEA at 3 and 8 cm above LES > 180 mmHg) and (iii) Spastic (DCI > 8000 mmHg‐s‐cm). Results: Forty‐one patients (segmental: 13, diffuse: 4, spastic: 24) satisfied study criteria. Patients with segmental NE would have been missed by conventional manometry criteria as their DEA < 180 mmHg. A higher percentage of patients with spastic NE (63%) had chest pain when compared to patients with segmental NE (23%) and diffuse NE (25%). There was a significant positive correlation between chest pain severity score and DCI while there was no significant correlation between dysphagia severity and DCI. Conclusions: In patients diagnosed with NE using the Chicago classification presence and intensity of chest pain increases with increasing DCI. The present criteria (> 5000 mmHg‐s‐cm) seems to be too sensitive and has poor symptom correlation. Adjusting the criteria to 8000 mmHg‐s‐cm is more relevant clinically.