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Normal liver elasticity values using acoustic radiation force impulse imaging: A prospective study in healthy living liver and kidney donors
Author(s) -
Son Chang Young,
Kim Seung Up,
Han Woong Kyu,
Choi Gi Hong,
Park Hana,
Yang Seung Choul,
Choi Jin Sub,
Park Jun Yong,
Kim Do Young,
Ahn Sang Hoon,
Chon Chae Yoon,
Han KwangHyub
Publication year - 2012
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2011.06814.x
Subject(s) - medicine , acoustic radiation force , percentile , nuclear medicine , magnetic resonance imaging , prospective cohort study , body mass index , elastography , ultrasound , radiology , statistics , mathematics
Background and Aim: Although several studies have investigated the normal range of liver elasticity using acoustic radiation force impulse (ARFI) elastography in healthy volunteers, they could not strictly exclude the morphological and functional liver abnormalities. The aim of this study was to identify the normal range of ARFI velocity by recruiting healthy living liver and kidney donors who passed the full laboratory tests and imaging studies. Methods: The study prospectively enrolled 108 healthy living liver ( n = 42) and kidney donors ( n = 66) who were admitted for transplantation between July 2010 to April 2011. None of the subjects had abnormal liver function test and imaging findings including conventional ultrasonography, computed tomography or magnetic resonance imaging. Results: The mean age of the study population (58 men and 50 women) was 35.5 years, and the mean ARFI velocity was 1.07 ± 0.11 m/s (range: 0.79–1.27). ARFI velocity was not significantly different between subjects with body mass index (BMI) < 23.5 kg/m 2 and those with BMI ≥ 23.5 kg/m 2 (1.05 ± 0.12 m/s vs 1.07 ± 0.10 m/s, P = 0.518), nor was it significantly different according to age ( P = 0.067) and gender (1.08 ± 0.12 m/s for men vs 1.05 ± 0.11 m/s for women, P = 0.085). Using the 5 th and 95 th percentiles, we determined the normal range and mean of ARFI velocity to be 0.85–1.25 m/s and 1.07 ± 0.11 m/s. Conclusions: We identified the normal range of ARFI velocity as 0.85–1.25 m/s and found that it was not significantly influenced by BMI, gender, and age.