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Can Helicobacter pylori ‐associated dyspepsia be categorized as functional dyspepsia?
Author(s) -
Suzuki Hidekazu,
Nishizawa Toshihiro,
Hibi Toshifumi
Publication year - 2011
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2011.06629.x
Subject(s) - helicobacter pylori , medicine , gastroenterology , placebo , spirillaceae , disease , clinical trial , helicobacter pylori infection , gastritis , alternative medicine , pathology
Evidence for an association between H. pylori and functional dyspepsia (FD) is uncertain. In the present review, we focused the special relevance of H. pylori infection to the development dyspepsia from the aspects of pathogensis, clinical efficacy of eradication of H. pylori in the West and in the East. Although clinical trials conducted to evaluate the efficacy of H. pylori eradication treatment for FD, including non‐ulcer dyspepsia (NUD), have yielded conflicting results, it is quite clear that H. pylori eradication treatment is effective at least in a subset of FD patients. In contrast to the previous results obtained in studies of Western populations, the result of a double‐blind, randomized, placebo‐controlled trial conducted in a Singapore suggests that patients with FD could benefit from H. pylori eradication therapy, with as much as a 13‐fold increase in the chance of symptom resolution. Especially in Asia, H. pylori should not be overlooked when considering the pathophysiology of FD. H. pylori ‐associated dyspepsia might be dealt as a different disease entity from FD.