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Clinical characteristics of TIMP2 , MMP2 , and MMP9 gene polymorphisms in colorectal cancer
Author(s) -
Park Kyung Sook,
Kim Seon Jeong,
Kim Kyung Ho,
Kim Jin Cheon
Publication year - 2011
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2010.06504.x
Subject(s) - colorectal cancer , metastasis , mmp2 , mmp9 , haplotype , medicine , single nucleotide polymorphism , matrix metalloproteinase , gastroenterology , cancer , oncology , cancer research , biology , gene , genotype , genetics , downregulation and upregulation
Background and Aim: Genetic variations and the expression profile of matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) are involved in the invasion and metastasis of colorectal cancer. Methods: The gene profiles of TIMP2 and MMP were assayed from 333 colorectal cancer using polymerase chain reaction–restriction fragment length polymorphism. Results: TIMP2‐418*G/ * G, TIMP2 303 * G/ * G and MMP9‐1562*C/ * C were more frequent in patients than in controls ( P = 0.020, P < 0.0001 and P < 0.044, respectively). Frequency of TIMP2‐418 * G/ * G was higher in patients with metastasis than in those without metastasis, and that of TIMP2 303 * G/ * G was higher in patients with rectal cancer than in those with colon cancer ( P = 0.008 and P = 0.022, respectively). TIMP2‐303 * A/ * A and MMP2‐1575 * G/ * G were less frequent in patients than in controls ( P = 0.001 and P = 0.005, respectively). The TIMP2‐418 * G303 * G haplotype was more frequent ( P < 0.0001) and MMP2‐1575 * G‐735 * C haplotype was less frequent in patients than in controls ( P = 0.005). Conclusion: Specific single‐nucleotide polymorphism in TIMP2 and MMP appeared to be associated with tumorigenesis and biological behavior in colorectal cancer, which is expected be further verified in a larger cohort in the future.