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Interleukin‐1β and ‐10 polymorphisms influence erosive reflux esophagitis and gastritis in Taiwanese patients
Author(s) -
Cheng HsinHung,
Chang ChiSen,
Wang HungJung,
Wang WenChing
Publication year - 2010
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2010.06310.x
Subject(s) - gastroenterology , medicine , odds ratio , helicobacter pylori , esophagitis , gastritis , genotype , confidence interval , reflux esophagitis , haplotype , reflux , disease , gene , biology , biochemistry
Background and Aims: Helicobacter pylori ( H. pylori ) infection induces cytokine production and is associated with gastrointestinal diseases. This study examined the relationship of gene polymorphisms, including interleukin ( IL ) ‐1β , ‐10 , ‐8 , and tumor necrosis factor‐α ( TNF‐α ), H. pylori infection, and susceptibility to gastrointestinal disorders in Taiwanese patients. Methods: IL‐1β −511/−31/+3953, ‐10 −1082/−819/−592, ‐8 −251, and TNF‐α −308 polymorphisms were assessed in 628 gastrointestinal disease patients, and 176 healthy controls were analyzed using the polymerase chain reaction−restriction fragment length polymorphism method. Results: IL‐1β −511 T/T and −31 C/C genotypes, and IL‐1β −511 T and −31 C alleles were associated with an increased risk of reflux esophagitis ( P = 0.034, odds ratio [OR] = 1.384, 95% confidence interval [CI]: 1.023–1.871; P = 0.031, OR = 1.388, 95% CI: 1.028–1.873; P = 0.044, OR = 1.342, 95% CI: 1.008–1.786; and P = 0.040, OR = 1.349, 95% CI: 1.014–1.796, respectively). No relationship was found between H. pylori infection and the risk of reflux esophagitis. IL‐10 −819 C/T and ‐10 −592 A/C genotypes and IL‐10 −1082/−819/−592 ATA/ACC and ATA/GCC haplotypes were associated with an increased risk of gastritis ( P = 0.021, OR = 1.721, 95% CI: 1.084–2.733; P = 0.016, OR = 1.766, 95% CI: 1.112–2.805; P = 0.039, OR = 1.662, 95% CI: 1.024–2.697; and P = 0.035, OR = 1.600, 95% CI: 1.024–2.499, respectively). Conclusion: Among Taiwanese patients, IL‐1β and ‐10 polymorphisms were associated with an increased risk of erosive reflux esophagitis and gastritis, respectively.