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Effects of mosapride on esophageal functions and gastroesophageal reflux
Author(s) -
Koshino Kenji,
Adachi Kyoichi,
Furuta Kenji,
Ohara Shunji,
Morita Terumi,
Nakata Shuji,
Tanimura Takashi,
Miki Masaharu,
Kinoshita Yoshikazu
Publication year - 2010
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2010.06280.x
Subject(s) - mosapride , reflux , medicine , gastroenterology , prokinetic agent , peristalsis , esophageal sphincter , proton pump inhibitor , gerd , esophagitis , disease
Background and Aim: A substantial number of patients with gastroesophageal reflux disease show symptomatic resistance to high‐dose proton pump inhibitors. In those cases, prokinetics are possible candidates for treatment. The aim of the present study was to determine whether mosapride, a prokinetic agent, stimulates esophageal functions, and prevents acidic and non‐acidic gastroesophageal reflux. Methods: Normal volunteers (nine and 13 for two experiments, respectively) were enrolled. Salivary secretion, esophageal peristaltic contractions, and resting lower esophageal sphincter pressure with and without mosapride administration were recorded using a cross‐over protocol. Post‐prandial acidic and non‐acidic reflux levels were also recorded. Results: Mosapride at a standard dose of 15 mg/day did not stimulate salivary secretion or any esophageal motor functions. It also failed to prevent acidic and non‐acidic post‐prandial gastroesophageal reflux. Conclusions: Mosapride at 15 mg/day, a standard dose in Japan, did not change the esophageal motility and salivary secretion in healthy volunteers. Future study on a larger number of individuals with higher dose of mosapride is worthwhile.