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Polymorphisms in promoter region of FAS and FASL gene and risk of gastric cardiac adenocarcinoma
Author(s) -
Zhou RongMiao,
Wang Na,
Chen ZhiFeng,
Duan YaNan,
Sun DongLan,
Li Yan
Publication year - 2010
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2009.06116.x
Subject(s) - fas ligand , genotype , odds ratio , single nucleotide polymorphism , haplotype , medicine , gastroenterology , snp , incidence (geometry) , case control study , immunology , oncology , biology , genetics , apoptosis , gene , programmed cell death , physics , optics
Background and Aim: The FAS and FASL system play an important role in regulating apoptotic cell death. This study was designed to investigate the correlation of FAS ‐1377 G/A, ‐670 A/G and FASL ‐844 T/C polymorphisms with susceptibility to gastric cardiac adenocarcinoma in a population of a high‐incidence region of Hebei Province. Methods: FAS ‐1377 G/A, ‐670 A/G and FASL ‐844 T/C polymorphisms were genotyped by polymerase chain reaction–restriction fragment length polymorphism analysis in 262 gastric cardiac carcinoma (GCA) patients and 524 healthy controls. Results: Family history of upper gastrointestinal cancer (UGIC) might increase the risk of developing GCA (age‐ and sex‐adjusted odds ratio [OR] = 1.38, 95% confidence interval [CI] = 1.02–1.86). The overall allelotype and genotype distributions of FAS ‐1377 G/A, and FASL ‐844 T/C polymorphisms in GCA patients did not significantly differ from that in healthy controls ( P > 0.05). Compared with individuals with a FAS ‐670 A/A genotype, individuals with an A/G genotype in a smoker group had a lower risk of developing GCA (age, sex, and family history of UGIC adjusted OR = 0.55, 95% CI = 0.34–0.88). When the genotypes of FAS and FASL single nucleotide polymorphisms (SNP) were combined to analyze, no significant correlation was found between these SNP and the risk for GCA development. Conclusion: In the high‐incidence region of Hebei Province, FAS ‐1377 G/A and FASL ‐844 T/C polymorphisms were not associated with the risk of GCA. However, the FAS ‐670 A/G genotype might decrease the risk of GCA for smoker individuals.