Premium
Comparison of p.o. or i.v. proton pump inhibitors on 72‐h intragastric pH in bleeding peptic ulcer
Author(s) -
Javid Gul,
Zargar Showkat Ali,
Khan Bashir Ahmad,
Yatoo Ghulam Nabi,
Shah Altaf Hussain,
Gulzar Ghulam Mohammad,
Sodhi Jaswinder Singh,
Khan Mushtaq Ahmad
Publication year - 2009
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2009.05900.x
Subject(s) - pantoprazole , omeprazole , medicine , rabeprazole , gastroenterology , bolus (digestion) , proton pump inhibitor , peptic , hemostasis , peptic ulcer
Background and Aims: After successful endoscopic hemostasis in bleeding peptic ulcer, addition of proton pump inhibitors reduce the rate of recurrent bleeding by maintaining intragastric pH at neutral level. The aim of the present study was to evaluate the effect of various proton pump inhibitors given through different routes on intragastric pH over 72 h after endoscopic hemostasis in bleeding peptic ulcer. Methods: Ninety consecutive patients who had successful endoscopic therapy of bleeding peptic ulcer underwent 72‐h continuous ambulatory intragastric pH study, were randomly assigned to receive p.o. omeprazole 80 mg bolus followed by 40 mg every 12 h for 72 h or i.v. 80 mg omeprazole followed by infusion 8 mg/h for 72 h. Oral pantoprazole 80 mg bolus followed by 80 mg every 12 h for 72 h or i.v. 80 mg pantoprazole followed by infusion of 8 mg/h for 72 h. Oral rabeprazole 80 mg bolus followed by 40 mg every 12 h for 72 h or i.v. 80 mg rabeprazole followed by infusion 8 mg/h for 72 h. Five patients received no treatment after successful endoscopic therapy and underwent 72‐h pH study. Results: Mean 72‐h intragastric pH for p.o. omeprazole was 6.56 versus 6.93 for omeprazole infusion ( P = 0.48). Mean 72‐h intragastric pH for p.o. pantoprazole was 6.34 versus 6.32 for pantoprazole infusion ( P = 0.62). Mean 72‐h intragastric pH for rabeprazole p.o. was 6.11 versus 6.18 rabeprazole i.v. ( P = 0.55). Mean 72‐h pH for the no proton pump inhibitor group was 2.04. Conclusion: There was no significant difference among various proton pump inhibitors given through different routes on raising intragastric pH above 6 for 72 h after successful endoscopic hemostasis in bleeding peptic ulcer.