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Normalization of pH level and gastric mucosa after eradication of H. pylori in the remnant stomach
Author(s) -
Kato Shunji,
Matsukura Norio,
Matsuda Noriko,
Tsuchiya Shinichi,
Naito Zenya,
Tajiri Takashi
Publication year - 2008
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2008.05447.x
Subject(s) - stomach , gastroenterology , medicine , intestinal metaplasia , atrophic gastritis , helicobacter pylori , gastritis , gastric mucosa , pepsin , gastrectomy , cancer , biology , enzyme , biochemistry
Background: The Updated Sydney System (USS) is used to evaluate chronic gastritis and chronic atrophic gastritis (CAG) due to H. pylori infection. Here, we investigated USS scores and gastric juice pH levels in H. pylori infection‐positive or ‐eradicated patients with remnant stomach after surgery. Methods: Gastric juice pH levels were measured using pH test‐tape in 197 patients (112 H. pylori ‐positive and 85 H. pylori ‐negative after eradication) who had undergone distal gastrectomy and conventional H. pylori eradication therapy. Results: In H. pylori infection‐positive remnant stomach cases, gastric juice pH showed a reverse correlation with pepsinogen I/II ratio, and H. pylori infection‐negative patients following eradication showed associations with the degree of atrophy and intestinal metaplasia at both the anastomosis and in the corpus. Further, pH levels in these patients were normalized time depending after the eradication in the remnant stomach. Conclusions: Eradication therapy for the remnant stomach contributes to the possible improvement of stomach conditions by controlling the pH level of gastric juice. This effect will be protective against the risk of secondary stomach carcinogenesis in the remnant stomach.