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Effect of the CYP2C19 polymorphism on the eradication rate of Helicobacter pylori infection by 7‐day triple therapy with regular proton pump inhibitor dosage
Author(s) -
Kang Jung Mook,
Kim Nayoung,
Lee Dong Ho,
Park Young Soo,
Kim Joo Sung,
Chang In Jin,
Song In Sung,
Jung Hyun Chae
Publication year - 2008
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2008.05392.x
Subject(s) - esomeprazole , cyp2c19 , clarithromycin , medicine , helicobacter pylori , pantoprazole , proton pump inhibitor , gastroenterology , regimen , amoxicillin , omeprazole , pharmacology , antibiotics , microbiology and biotechnology , biology , cytochrome p450 , metabolism
Background and Aim: Proton pump inhibitors (PPI) are mainly metabolized by cytochrome P450 2C19 (CYP2C19) in the liver. We investigated whether the CYP2C19 genotype plays a role in the eradication rate of Helicobacter pylori ( H. pylori ) infection in patients receiving pantoprazole‐ or esomeprazole‐based triple therapy. Methods: A total of 327 patients infected with H. pylori were treated with either pantoprazole or esomeprazole, plus amoxicillin and clarithromycin for 7 days. The presence of the CYP2C19 genotype was determined by pyrosequencing. Results: The overall H. pylori eradication rate was 85%; 82.6% for the PAC regimen, and 88.3% for the EAC regimen; the differences were not statistically significant. The overall eradication rate in the poor metabolizer groups (PM) was significantly higher than in the extensive metabolizer groups (EM) (97.4% vs 83.3%; P = 0.016). The eradication rates in the EM and PM groups were 80.8% and 95.7% for the PAC regimen and 86.8% and 100% for the EAC regimen, respectively. Conclusion: The results of this study suggest that the CYP2C19 genotype status may play a role in the H. pylori eradication rate in patients receiving pantoprazole or esomeprazole‐based triple therapy.