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Artemisia asiatica extracts protect against ethanol‐induced injury in gastric mucosa of rats
Author(s) -
Park Sang Woon,
Oh Tae Young,
Kim Yong Seok,
Sim Hyejin,
Park Sang Jong,
Jang Eun Jung,
Park Joo Sang,
Baik Hyun Wook,
Hahm Ki Baik
Publication year - 2008
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2008.05333.x
Subject(s) - medicine , gastric mucosa , pharmacology , artemisia , glutathione , ethanol , lipid peroxidation , cytoprotection , liver injury , inflammation , stomach , traditional medicine , immunology , biochemistry , oxidative stress , chemistry , enzyme
Background and Aim: Based on our previous studies that Artemisia asiatica extracts exert either antioxidative or cytoprotective actions against non‐steroidal anti‐inflammatory drugs or Helicobacter pylori ‐induced gastric mucosal injury, or imposes qualified ulcer healing in an acetic acid‐induced gastric ulcer model, we investigated the protective effects of Artemisia asiatica extracts against ethanol‐induced gastric mucosal injury. Methods: Sprague–Dawley rats received 4 g/kg body weight (BW) of absolute ethanol intragastrically, which produced visible hemorrhagic gastric lesions 60 min later. Results: In this animal setting, the pretreatment of Artemisia extracts (30 or 100 mg/kg BW), 1 h before ethanol administration, significantly attenuated the source of gastric injury, which was assessed with gross and microscopic analysis ( P < 0.01). Protection from alcohol‐induced damage with Artemisia pretreatment was associated with significantly decreased lipid peroxidation, protecting gastric mucosa from glutathione depletion, as well as the inhibition of the cytochrome 2E1 ethanol‐metabolizing enzyme. It attenuated the expressions of ethanol‐induced pro‐inflammatory cytokines, including interleukin (IL)‐1β and interferon‐γ, a weak activation of IL‐10, the inhibition of the alcohol‐induced overexpression of intercellular adhesion molecule‐1, and the considerable induction of heat shock protein‐72 expression in gastric mucosal homogenates . Conclusion: The data suggest that the ethanol extracts of Artemisia asiatica exerted significant protection from alcohol‐induced gastric mucosal injury through bioregulation, which is essential for cytoprotection and anti‐inflammation.