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Association between low thigh fat and non‐alcoholic fatty liver disease
Author(s) -
Jun Dae Won,
Han Jee Hye,
Kim Sang Heum,
Jang Eun Chul,
Kim Nam In,
Lee Jun Seok,
Song Moon Hee,
Kim Seung Hwan,
Jo Yoon Ju,
Park Young Sook
Publication year - 2008
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2008.05330.x
Subject(s) - medicine , fatty liver , body mass index , thigh , intramuscular fat , intra abdominal fat , adipose tissue , endocrinology , quartile , obesity , gastroenterology , disease , surgery , visceral fat , insulin resistance , confidence interval , biology , biochemistry
Background and Aim: Some people have a fatty liver despite having low visceral fat and a low body mass index (BMI). We investigated whether fat distribution, especially thigh subcutaneous fat and thigh intramuscular fat, is associated with non‐alcoholic fatty liver disease (NAFLD). Methods: The patients consisted of 408 men and women. NAFLD was defined by an ultrasound scan and excluded other liver diseases. Visceral, subcutaneous abdominal, intramuscular, and subcutaneous thigh adipose tissue was measured by computed tomography. Results: The frequency of NAFLD decreased over a quartile of thigh fat independently of BMI in the female patients. Additional adjustments for age and visceral fat area did not change the results. This finding was not observed in the male patients. To investigate the relationship between each fat distribution and NAFLD, we performed a logistic regression analysis. Fat distribution was divided into four groups: visceral fat, abdominal subcutaneous fat, thigh subcutaneous fat, and thigh intramuscular fat. All four fat components were chosen as variables for the regression model. Age, BMI, and the homeostasis model assessment (HOMA) index were then adjusted successively. A larger subcutaneous fat area was negatively associated with NAFLD after adjustment for visceral fat and abdominal subcutaneous fat areas in women, but not in men. It did not change even after age adjustment, BMI, and the HOMA index. Conclusion: Low femoral subcutaneous fat amounts were shown to be independently associated with fatty liver disease in women. These results show the importance of accurate measurements of other regional body compositions as well as visceral fat amounts when investigating NAFLD.