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Hyperglycemia and hypertriglyceridemia may associate with the adenoma–carcinoma transition in colorectal epithelial cells
Author(s) -
Tabuchi Masafumi,
Kitayama Joji,
Nagawa Hirokazu
Publication year - 2008
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2007.05072.x
Subject(s) - medicine , hypertriglyceridemia , colorectal cancer , adenoma , gastroenterology , colonoscopy , odds ratio , colorectal adenoma , carcinoma , risk factor , oncology , cancer , triglyceride , cholesterol
Background and Aim: Epidemiological studies have suggested the positive correlation between hyperlipidemia and/or hyperglycemia and colorectal cancer risk. Methods: We retrospectively examined the association between fasting blood sugar (BS) or triglycerides (TG) and the presence of colorectal adenoma, carcinoma in situ and invasive cancer in 867 patients who received total colonoscopy by medical health check. Results: An increased TG level, but not a BS level, was significantly associated with the increased risk of adenoma, although with non‐independent multivariate analysis. In contrast, an elevated BS level was identified as an independent risk factor for invasive cancer in 93 patients with carcinoma lesions with an odds ratio of 1.74 ( P < 0.05). Conclusion: Our data suggest that hypertriglyceridemia and hyperglycemia may correlate with the development of adenoma and invasive cancer, respectively. The effectiveness of strict BS control in patients with hypertriglyceridemia for the prevention of the invasive colorectal carcinoma deserves further studies.