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Polymorphisms in NFKBIA and ICAM‐1 genes in New Zealand Caucasian Crohn's disease patients
Author(s) -
Hong Jiwon,
Leung Euphemia,
Fraser Alan G,
Merriman Tony R,
Vishnu Prakash,
Krissansen Geoffrey W
Publication year - 2007
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2007.05020.x
Subject(s) - medicine , crohn's disease , inflammatory bowel disease , allele , immunology , disease , nod2 , gene , icam 1 , gastroenterology , biology , genetics , cell adhesion molecule
Background and Aim: Crohn's disease (CD) is a complex polygenetic inflammatory disease of the bowel. NFKBIA (IκBα) is a downstream regulator of NF‐κB, which is an effector of the major Crohn's susceptibility gene CARD15/NOD2 . ICAM‐1 is an integrin ligand and vascular addressin, which contributes to the trafficking of pathogenic leukocytes into the inflamed bowel. Here we examined whether the NFKBIA 2758G/A and ICAM‐1 K469E variants, recently shown to be CD susceptibility genes in Caucasian populations in Germany and the United Kingdom, are associated with CD in Caucasian patients in New Zealand. Methods: PCR‐RFLP analysis was used to examine the frequency of gene polymorphisms in 182 CD patients and 188 ethnically matched controls. Results: There was no significant evidence of a difference in the allele frequency of either the 2758G/A polymorphism in NFKBIA (0.38 vs 0.35, P = 0.47) or the K469E polymorphism in ICAM‐1 (0.43 vs 0.37, P = 0.10) between CD patients and controls. Nevertheless, the ICAM‐1 469E allele significantly ( P = 0.016, Pc = 0.047) influenced the age of diagnosis of CD. Meta‐analysis with five other studies confirmed a lack of association of the K469E polymorphism with Crohn's disease ( P = 0.33; OR = 0.93; 95% CI, 0.82–1.07). Conclusion: The NFKBIA 2758G/A and ICAM‐1 K469E polymorphisms are not significant risk factors for CD in New Zealand; however, there is evidence that the latter polymorphism influences the age of diagnosis.