Premium
Rabeprazole delays gastric emptying of a nutrient liquid
Author(s) -
Sanaka Masaki,
Anjiki Hajime,
Yamamoto Takatsugu,
Kuyama Yasushi
Publication year - 2007
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2006.04763.x
Subject(s) - gastric emptying , rabeprazole , medicine , ingestion , gastroenterology , digestion (alchemy) , breath test , excretion , meal , gastric acid , stomach , chemistry , helicobacter pylori , chromatography
Background: It is generally considered that gastric acid suppression delays gastric emptying of solid meals because gastric hypoacidity impairs peptic digestion and antral triturition. Rabeprazole is one of the most potent acid suppressants. We conducted this cross‐over study to investigate if rabeprazole delays gastric emptying of liquid nutrients, for which peptic digestion is unnecessary. Methods: On two randomized occasions, 13 healthy male volunteers underwent the 13 C‐acetate breath test following ingestion of a 300 kcal‐liquid meal. On one occasion, they had received 20 mg rabeprazole for the preceding 2 days and 1 h before the test. On another, they took no pretreatment. Based on 4 h breath samples, the half 13 CO 2 excretion time (t 1/2b ) and the time of maximal excretion (t max ) were calculated as overall measures of gastric emptying. In addition, time profiles of gastric emptying were generated using the Wagner‐Nelson analytical method, which creates the gastric emptying curve as accurately as the scintigraphy. Results: Rabeprazole significantly prolonged t max but unchanged t 1/2b . The gastric emptying profiles showed that rabeprazole evoked a segmental slowing of gastric emptying during 0.5–1.25 h of post‐meal ingestion. Conclusions: Rabeprazole suppresses gastric emptying of a liquid nutrient 0.5 h after meal ingestion. We have speculated that: (i) rabeprazole delays gastric emptying via a mechanism other than acid‐pepsin maldigestion; and (ii) rabeprazole may intensify the post‐gastric feedback regulation system (>0.5 h of post‐meal).