Premium
Comparison of liver histopathology between chronic hepatitis C patients and chronic hepatitis B and C‐coinfected patients
Author(s) -
Lee LiPo,
Dai ChiaYen,
Chuang WanLong,
Chang WenYu,
Hou NeiJen,
Hsieh MingYen,
Lin ZuYau,
Chen ShinnCherng,
Hsieh MingYuh,
Wang LiangYen,
Chen TongJong,
Yu MingLung
Publication year - 2007
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2006.04547.x
Subject(s) - medicine , coinfection , histopathology , hbsag , gastroenterology , fibrosis , necrosis , hepatitis b , hepatitis b virus , hepatitis , pathology , immunology , virus
Background: The aim of the present study was to compare the histological characteristics of livers between chronic hepatitis C (CHC) patients with and without hepatitis B virus (HBV) coinfection. Methods: A total of 336 CHC patients (male/female: 204/132, mean age: 46.1 ± 11.7 years) were enrolled in the study; 32 patients (9.8%) were positive for hepatitis B surface antigen (HBsAg). The histological characteristics of livers were described according to the Knodell and Scheuer scoring system. Results: The proportion of non‐intralobular necrosis (score 0) was significantly lower and the mean intralobular necrosis score was higher among CHC patients with HBV coinfection than those without coinfection (43.8% vs 64.5%; 0.84 ± 1.05 vs 0.53 ± 0.89). The epidemiological and virological parameters, and other histological scores (periportal necrosis, portal inflammation, total necroinflammation and fibrosis) were not significantly different between these two groups. Conclusion: Chronic hepatitis C patients with HBV coinfection tend to have more severe intralobular necrosis than those with isolated HCV infection.