Premium
Rebamipide enema therapy as a treatment for patients with active distal ulcerative colitis
Author(s) -
Furuta Ryuichi,
Ando Takafumi,
Watanabe Osamu,
Maeda Osamu,
Ishiguro Kazuhiro,
Ina Kenji,
Kusugami Kazuo,
Goto Hidemi
Publication year - 2007
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1111/j.1440-1746.2006.04399.x
Subject(s) - rebamipide , medicine , enema , ulcerative colitis , gastroenterology , colitis , corticosteroid , refractory (planetary science) , disease , physics , astrobiology
Background: The clinical efficacy of corticosteroids in the treatment of ulcerative colitis (UC) is well‐established. However, prolonged usage of these drugs can result in serious complications. Rebamipide {2‐(4‐chlorobenzoylamino)‐3[2‐(1H)‐quinolinon‐4‐yl] propionic acid}, a cytoprotective agent, has been reported to have anti‐inflammatory activity and to repair mucosal injury in animal colitis models. The aim of the present study was to assess the clinical efficacy and safety of a novel Rebamipide enema therapy in UC patients. Methods: Twenty patients with the active distal type of UC in whom corticosteroid treatment had been unsuccessful were treated with rectal administration of Rebamipide twice a day for 3 weeks, during which corticosteroid dosage was kept constant. The efficacy of treatment was assessed from clinical symptoms and endoscopic findings. The anti‐inflammatory effect of Rebamipide was also examined by monitoring changes in the intensity of histological inflammation and levels of cytokine activity in the rectal mucosa. Results: At 3 weeks after the initiation of Rebamipide enema therapy, 11 patients (55%) achieved clinical remission. Sixteen (80%) were colonoscopically judged to be responders, with decreased levels of interleukin (IL)‐1β but not of IL‐8, and an increased ratio of IL‐1 receptor antagonist/IL‐1β in organ cultures of mucosal tissues. The change in the number of infiltrating neutrophils was not significantly correlated with the clinical response to this therapy. No side‐effects were noted in any patients. Conclusion: Rebamipide enema therapy proved to be safe and useful in corticosteroid‐refractory patients with the active distal type of UC.